T-CellAmp

T-CellAmp FAQs

1. What is T-CellAmp?

T-CellAmp is a small molecule amplifier of T cell activation. It is used to drive the in vivo growth of T cell therapies like CAR-T and TCR-T cells and increase their therapeutic potential.

2. How is T-CellAmp used?

T-CellAmp is used during initial activation of T cells. It is typically removed 24 hours later.

5. Why should I use T-CellAmp in the manufacturing of CAR-T cells?

Growing T cells for an in vivo experiment or for injection into a patient is a time-consuming and costly process. The more T cells proliferate, the more differentiated they become. Differentiated T cells lose their capacity to proliferate and are short-lived, once injected into an animal or a patient.

T cells activated in the presence of T-CellAmp maintain their ability to proliferate after injection into an animal or a patient leading to a shorter ex vivo expansion time and a lower cell number to achieve a similar therapeutic outcome. T-CellAmp reduces the manufacturing cost of CAR-T cells and decreases the need for bridge therapies, while patients await the growth of their CAR-T cells.

6. Is T-CellAmp a clinical reagent?